In today’s JAMA Neurology, researchers led by Oskar Hansson, Lund University, Sweden, report how a fully automated immunoassay for plasma Aβ performed when they put it through its paces. Roche Diagnostic’s Elecsys system predicted Aβ-positive individuals with about 80 percent accuracy. That number improved by 5 percent when the researchers took ApoE genotype into consideration. Alzforum first reported on this data when Hansson presented it at AAIC in 2018 (Aug 2018 conference news ). Since then, first author Sebastian Palmqvist and colleagues have tested samples in a validation cohort in Germany. Here the test was more accurate, at 86 percent. “I think we are not that far away from a blood-based biomarker that can be implemented in primary care to improve diagnostics of AD,” Hansson told Alzforum.
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