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Neuroinflammatory astrocyte subtypes in the mouse brain
24/05/2022 @ 5:00 pm - 6:00 pm
Astrocytes undergo an inflammatory transition after infections, acute injuries and chronic neurodegenerative diseases. How this transition is affected by time and sex, its heterogeneity at the single-cell level and how sub-states are spatially distributed in the brain remains unclear. In this webcast, Dr. Shane Liddelow of NYU Langone’s Neuroscience Institute will present a transcriptomic investigation of mouse cortical astrocytes after an acute inflammatory stimulus.
The study identifies fast transcriptomic changes in astrocytes occurring within hours that drastically change over time. Sequencing ~80,000 astrocytes at single-cell resolution shows that inflammation causes a widespread response with subtypes of astrocytes undergoing distinct inflammatory transitions with defined transcriptomic profiles. The work also attributes key sub-states of inflammation-induced reactive astrocytes to specific brain regions using spatial transcriptomics and in situ hybridization.
Together, these datasets provide a powerful resource for profiling astrocyte heterogeneity and will be useful for understanding the biological importance of regionally constrained reactive astrocyte sub-states.
- Understand the diversity and heterogeneity of CNS astrocytes
- Discover how single-cell transcriptomics can be leveraged to assess the heterogenous response of cell subsets undergoing distinct reactions to pathological stimuli
- Learn how different astrocyte subtypes are distributed in the brain
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