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X-WR-CALDESC:Events for DEMENTIA RESEARCHER
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DTSTART;VALUE=DATE:20260112
DTEND;VALUE=DATE:20260115
DTSTAMP:20260408T132513
CREATED:20251203T225307Z
LAST-MODIFIED:20251203T225307Z
UID:10002011-1768176000-1768435199@www.dementiaresearcher.nihr.ac.uk
SUMMARY:Human Amyloid Imaging Conference
DESCRIPTION:The overall goal of the Human Amyloid Imaging conference is to support active communication and collaboration between academic and industry scientists doing cutting-edge research in human imaging of amyloid-beta\, tau\, and/or other biomarkers that pertain to Alzheimer’s disease and related disorders. \nHAI 2026 will be held once again in beautiful San Juan\, Puerto Rico\, at the Puerto Rico Convention Center\, from Monday\, January 12 through Wednesday\, January 14. \nThe meeting will also provide related perspectives from neuropathology\, neurochemistry\, psychology\, neurology\, molecular imaging\, clinical trials\, and biomarker research. \n\nAttendees will have the opportunity to review the basic\, fundamental principles of PET imaging of amyloid and tau radiotracers. This includes radiotracer synthesis\, PET acquisition and data processing (e.g.\, application of corrections for the partial volume effect\, co-registration with structural data). Aspects of radiotracer discovery and optimization and first in human applications are other important topics.\nData analysis procedures discussed will include voxel-based and region-based imaging approaches\, masking for vulnerable regions\, evaluation of reference regions or standards\, choice of statistical procedures and specific use of control groups from older age groups. Important topics include data harmonization methods for imaging and biofluid biomarkers.\nNeuropathology concepts will be discussed in the context of applications that include further characterization of neurodegeneration in AD and related disorders\, disease subtypes\, disease staging\, and risk factors. Additional investigations of importance include neuropathological evaluation of PET radiotracer properties (e.g.\, distribution\, localization of specific and off-target binding) and correspondence between antemortem PET and postmortem measures.\nBiofluid biomarker development\, validation\, and application in AD and related disorders will be discussed. This will include efforts to understand relationships across established and emergent biofluid biomarkers and comparison of these outcomes to amyloid and tau PET measures.\nThe concept of biomarker positivity will continue to be extensively discussed\, and the attendees should be able to characterize the advantages and disadvantages of both dichotomized and continuous variable approaches to imaging and non-imaging biomarkers relevant to the human amyloid imaging field and with respect to specific purposes or intended uses of the outcome.\nAttendees will have the opportunity to evaluate amyloid and tau data in specific clinical and clinical research contexts\, including review of typical findings in AD dementia\, mild cognitive impairment due to AD\, and in clinically normal individuals. This includes further elucidation of factors that underlie relationships between amyloid and tau deposition\, cognitive decline\, and dementia progression that provide a more informed understanding of individual patient trajectories. These efforts will also be related to familial forms of the disease\, Down Syndrome\, and to non-AD processes (i.e.\, fronto-temporal lobar degeneration and Lewy Body dementia). Further study of “real world” research participants will be discussed that includes people from diverse\, ethnic and/or racial minority\, and disadvantaged groups.\nParticular attention will be given to the assessment of longitudinal amyloid and tau PET data as it relates to methods of analysis and comparison to other domains of data\, including structural and functional brain imaging data\, and clinical and cognitive outcomes. An ongoing topic of importance is the relative value of PET versus other detection strategies (e.g.\, MRI volumetry and biofluid biomarkers).\nAttendees will also continue to have the opportunity the better understand methodology that can be used to optimize participant selection and conduct of AD therapeutic trials. Important topics relate to improved understanding of how in vivo metrics (imaging and non-imaging) and cognition change in response to AD therapeutic treatment (cross-sectionally and longitudinally) and how to better identify those most vulnerable to treatment side-effects\, such as anti-amyloid related imaging abnormalities.\n\nFind out more and register
URL:https://www.dementiaresearcher.nihr.ac.uk/event/human-amyloid-imaging-conference/
CATEGORIES:Conference
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DTSTART;TZID=Europe/London:20260114T093000
DTEND;TZID=Europe/London:20260114T163000
DTSTAMP:20260408T132513
CREATED:20251206T223401Z
LAST-MODIFIED:20251218T195254Z
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SUMMARY:Practical Laboratory Skills
DESCRIPTION:Having the knowledge and confidence to work safely in the laboratory is an essential skill for all staff working in laboratories. This course will cover basic theoretical and practical laboratory skills including preparing COSHH risk assessments\, good laboratory practice\, use of fume hoods/biosafety cabinets\, centrifuges and other laboratory equipment\, pipetting skills\, using balances and preparing reagents and solutions. \nA sustainability module is also included to highlight ways to reduce the environmental impact of laboratory work. Participants will explore practical ways to improve sustainability in the laboratory by reducing energy consumption and minimising the use of plastics and water and promoting more sustainable supply chain practices. \nWho is this for? \n\nResearch Staff\nTechnical Staff and students new to the laboratory environment\nExperienced personnel looking to refresh their skills\n\nAfter the course you will be able to: \n\nPrepare and understand the purpose of Control of Substances Hazardous to Health (COSHH) risk assessment (RA) forms\nUnderstand the importance of good laboratory practice\, including choosing appropriate personal protective equipment (PPE) and maintaining accurate laboratory records\nCorrectly use fume hoods\, biosafety cabinets\, centrifuges and other general laboratory equipment\nChoose the correct pipette for your task and perform common techniques\nSet up and use balances correctly\nPrepare reagents and solutions\nAdjust the pH of solutions\nIncorporate sustainability considerations into laboratory work to support efficient and environmentally responsible research\n\n\nThis training is approved by the Royal Society of Biology. Training course approval is an independent review process that recognises relevant\, high quality training. Upon completion of this course\, attendees can claim 21 CPD points. \nRegister to Attend
URL:https://www.dementiaresearcher.nihr.ac.uk/event/practical-laboratory-skills/
LOCATION:MRC Harwell\, Becquerel Avenue\, Harwell\, Didcot\, Oxfordshire\, OX11 0RD\, United Kingdom
CATEGORIES:Training
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DTSTART;TZID=Europe/London:20260114T200000
DTEND;TZID=Europe/London:20260114T204500
DTSTAMP:20260408T132513
CREATED:20260105T115417Z
LAST-MODIFIED:20260128T211829Z
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SUMMARY:Catchup - Understanding Apathy in Dementia
DESCRIPTION:Apathy is one of the most common symptoms in dementia and one of the least well understood. This session asks a simple question. What is really going on when people stop acting. \nThis livestream is part of the Dementia Researcher weekly ‘Showcase’ series. Each week we host a 45 minute online session that brings researchers together to share work. \nIn this session\, Rebecca Williams will focus on apathy in dementia\, with particular attention to frontotemporal lobar degeneration. She will introduce a different way of thinking about apathy\, not as a simple lack of motivation\, but as a loss of confidence in the outcomes of action. Drawing on her PhD research\, she will explain how this shift in thinking\, alongside computational modelling\, is helping to generate new insights into causes and potential approaches to treatment. \nRebecca is a PhD student specialising in dementia research at the MRC Cognition & Brain Sciences Unit in Cambridge. Attendees can expect a clear and accessible talk\, grounded in current research\, with time for questions and discussion at the end. \n\nWatch the Recording
URL:https://www.dementiaresearcher.nihr.ac.uk/event/research-showcase-understanding-apathy-in-dementia/
LOCATION:Dementia Researcher Communities App
CATEGORIES:Showcase
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