BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//DEMENTIA RESEARCHER - ECPv6.14.0//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:DEMENTIA RESEARCHER
X-ORIGINAL-URL:https://www.dementiaresearcher.nihr.ac.uk
X-WR-CALDESC:Events for DEMENTIA RESEARCHER
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:Europe/London
BEGIN:DAYLIGHT
TZOFFSETFROM:+0000
TZOFFSETTO:+0100
TZNAME:BST
DTSTART:20260329T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0100
TZOFFSETTO:+0000
TZNAME:GMT
DTSTART:20261025T010000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Europe/London:20260528T150000
DTEND;TZID=Europe/London:20260528T160000
DTSTAMP:20260525T170550
CREATED:20260504T203253Z
LAST-MODIFIED:20260504T203253Z
UID:10002223-1779980400-1779984000@www.dementiaresearcher.nihr.ac.uk
SUMMARY:Cognitive Rejuvenation through OSK
DESCRIPTION:Restoring seemingly lost bodily functions in age and age-related disorders has\, over recent years\, transitioned from the realm of science fiction to tangible research questions with high translational potential. Among the available approaches\, partial cellular reprogramming has emerged as one of the most promising strategies to promote tissue regeneration and restore cellular function\, while at the same time preserving cellular identities. However\, whether this approach bears fruit to rejuvenate cognitive processes has remained unknown until recently. \nIn this talk\, Prof. Johannes Gräff will highlight recent findings from his laboratory\, which show that partial reprogramming of engram neurons – bona fide memory trace cells – by OSK-mediated gene therapy leads to cognitive rejuvenation. This intervention reverses the expression of senescence and disease-related cellular hallmarks in aged mice and models of Alzheimer’s disease (AD)\, re-establishes aberrant epigenetic-transcriptional patterns pertaining to synaptic plasticity and counteracts AD-typical neuronal hyperexcitability. Importantly\, irrespective of the brain area targeted or the behavioural paradigm employed\, engram reprogramming also restores learning and memory capacities to levels comparable of healthy young animals. These results posit that partial reprogramming of defined cell populations in the brain can be translationally exploited for cognitive restoration in aging and disease. \nEvent details: \n• Date: 28.05.2026\n• Time: 16:00\n• Duration: 45 minutes (includes Q&A)\n• Location: Online (link to be provided upon registration)\n• Costs: Free of charge \nReferent: Prof. Johannes Gräff\, EPFL \n\nRegister
URL:https://www.dementiaresearcher.nihr.ac.uk/event/cognitive-rejuvenation-through-osk/
LOCATION:Online\, United Kingdom
CATEGORIES:Workshop
ATTACH;FMTTYPE=image/png:https://www.dementiaresearcher.nihr.ac.uk/wp-content/uploads/2025/03/Swiss-Network-for-Dementia-Research-logo.png
END:VEVENT
END:VCALENDAR