Genome Editing Mice for Medicine Call Open

Could genome editing advance your research? Do you need a genetically altered mouse line for discovery and clinical research?

Applications are now open for the 7th GEMM call – a bespoke service delivered by MRC Harwell to advance biomedical science. Successful applicants demonstrating the importance of their desired model will have their novel mouse line designed free of charge and made publicly available.

Applications close on the 1st July 2020. Successful applicants will be notified after the panel review meeting.

For any questions please contact gemm@har.mrc.ac.uk


Who can apply:

The MRC’s standard guidance for eligibilty apply. Please refer to Section 1.1 of the MRC Guidance for Applicants.

Applicants are expected to have the necessary interests, expertise (e.g. in working with animals), licences and facilities in place to deliver their experimental plans.

The MRC encourages and supports collaborative research projects and team approaches.

We do not expect MRC’s large and flexible strategic investments (e.g. institutes, units, regenerative medicine hubs etc) to access the GEMM resource, given existing substantial, long-term funding that can be deployed to support this type of work.

Guidance for applicants:

  1. Applications are invited for the nomination of specific genetic alterations in the mouse using genome editing technologies.
  2. The following allele types/methodologies are available in this call (subsequent calls will reflect developments in genome editing technologies):
    • Indels
    • Deletions
    • Point mutation insertions
    • Cassette Knock-ins
    • Conditional or Tm1a allele generation
  3. In addition to single mouse lines, nominations for collections or groups of lines within a specific theme/discipline will be considered.
  4. Applicants are required to submit an online application that outlines:
    • The nominator’s own research hypotheses and specific research plans for utilising the mouse;
    • The beneficial impact that generation of the proposed novel mouse line will have on the wider academic community;
    • Funding plans for supporting the described experimental work.
    • Collaborators may supply an optional letter of support which outlines the potential impact on their own research of the mouse line nominated.
  5. Principle Investigators will be expected to demonstrate research excellence and a proven track record in their proposed field of study.
  6. Home Office authorisation and ethical review should already be in place for subsequent studies on the mouse line nominated.

Additional details:

As set out in the MTA, the MLC will not claim ownership of or any rights to any data, results, materials (including modifications) or intellectual property produced by the recipient scientists as a result of their use of the materials supplied.

  1. The MLC will commence work to produce a line within 6 months of the nomination’s success, however the completion date will depend upon technical complexity and biological viability.
  2. All intellectual property for the lines generated remains with the MRC. Issues of intellectual property are outlined within the MTA to be signed by the PI, their host institution and the MLC. Acceptance of the supplier MTA is a condition of this award and no negotiation of the terms may be entered into.
  3. All experimental research plans disclosed in the application process will remain confidential to the review panel and MRC staff involved in managing the application process.
  4. The details of the mice generated under this award will be published on the MRC Harwell website ( http://www.mousebook.org/ ) and submitted to the EMMA database ( https://www.infrafrontier.eu/search ).
  5. There is no limit to the number of applications per establishment or individual scientist.

Visit funding web page
(https://www.har.mrc.ac.uk/international-programmes/gemm/)