PhD Studentship Discover Molecular Origins of Alzheimer’s Disease

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Website Macquarie_Uni Macquarie University

Closing date: 31st March

PhD Studentship: Protein Chemistry to Discover the Molecular Origins of Alzheimer’s Disease

Macquarie University, Sydney, Australia

Supervisory Team: Dr Ole Tietz, Prof Lars Ittner

Project Description

Considering a career at the intersection of Chemistry and Neuroscience research? Did you recently or are you about complete your studies in Chemistry or related field and were thinking about a PhD? Want to acquire a Master of Research along the way? – The Dementia Research Centre (DRC) is offering a MRes/PhD-stipend to work on cutting edge Protein Chemistry and investigate the molecular origins of Alzheimer’s Disease. Posttranslational modifications (PTMs) govern the function of a variety of disease associated proteins and convey pathological pathways – these modifications can be introduced through chemical synthesis to study their impact on disease progression and rationally design novel therapies. The TAU protein is central to the pathogenesis of Alzheimer’s disease and PTMs of TAU remain poorly understood. This project aims at deciphering the roles of different PTMs in TAU biology and disease using a wide range of technologies, including macromolecular chemistry and CRISPR genome editing. The multidisciplinary research program of the Dementia Research Centre at Macquarie University provides ample opportunities to learn and apply cutting-edge technologies to decipher mechanism in brain function and diseases. Please follow the links for more information on the DRC (https://www.mq.edu.au/research/research-centres-groups-and-facilities/healthy-people/centres/dementia-research-centre) and study opportunities in the DRC (https://www.youtube.com/watch?v=kj1qY0cNWF8).

Entry Requirements

An undergraduate degree (at least a UK 2:1 honours degree or equivalent) in Chemistry, Biochemistry, Biomedical Sciences, Bioengineering and allied subjects/relevant disciplines. Enthusiasm to work in an interdisciplinary environment with a strong interest in Protein Chemistry, Neurosciences, and Alzheimer’s disease is highly desirable. Training in all areas of the PhD and professional development opportunities will be provided.

This scholarship is available to eligible candidates to undertake a MRes Year 2 + PhD Bundle program or direct entry 3-year PhD program. Excellent candidates may be considered for direct entry into the PhD program in accordance with HDR rules at Macquarie University.

Closing Date: 31/March/2022

Funding: The scholarship is comprised of a Tuition Fee Offset and a Living Allowance Stipend. The value and tenure of the scholarship is a “MQRES” full-time stipend rate of AU$28,597 per annum (in 2021 tax exempt for up to 4 years – indexed annually).

How to apply

To find out more about the project please contact Dr Ole Tietz (ole.tietz@mq.edu.au). Please quote reference 20213730 on your application and in any correspondence about this vacancy.

All applications require full supporting documentation and a covering letter, including supporting statement indicating how the applicant’s expertise and interests link to the project.

To apply for this job email your details to ole.tietz@mq.edu.au.

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