PhD Studentship, University of Salford
Research project: Investigating the relationship between autophagy and exosomal miRNA in Alzheimer’s disease and frontotemporal dementia.
The increasing incidence of dementia poses a significant global health challenge due to the substantial socio-economic impact on society and devastating effect it has on the families impacted by it. The diseases that cause dementia, such as Alzheimer’s disease (AD) and frontotemporal dementia (FTD), are pathologically characterised by the abnormal accumulation of proteins such as hyperphosphorylated tau, β-amyloid and aggregated TDP-43, and these are known to have neurotoxic effects. Previous work in our group has shown impairments of the autophagy pathways that usually function to clear the abnormal accumulation of these proteins and the hierarchical deposition of these proteinaceous deposits and spread of neurodegenerative disease pathogenesis has been linked to small extracellular vesicles (sEV’s) which have been shown to contain disease associated cargoes such as miRNA’s.
This project will explore the relationship between autophagy and sEV miRNA expression in Alzheimer’s disease (AD) and frontotemporal dementia (FTD) using human brain tissue and cellular based models of disease. Investigating variations in sEV cargoes across different dementia subtypes will further our understanding of variations in disease processes and also enable the identification of novel, potential disease biomarkers for use in the early detection and diagnosis of disease.
You will join a supportive team at the University of Salford who are passionate about improving the lives of those impacted by dementia. Applicants should be motivated and enthusiastic scientists with an interest in science communication and outreach.
This funding covers UK tuition fees, bench fees and a Doctoral stipend matching UK Research Council National Minimum.
Applicants should possess a minimum of an upper second class Honours degree, Master’s degree, or equivalent in a relevant subject.
Applicants whose first language is not English are normally expected to meet the minimum University requirements (i.e. 6.5 IELTS)
More details are on Alzheimer’s Society page. This studentship has a start date of September 2021 and the deadline for submission is 4pm Friday 6th August.
You may use the information in this advert as the funding proposal and include the following in your application;
• Supporting statement
• Qualification certificates
• References x 2
• Proof of English language (if applicable)
To apply for this job please visit apply.salford.ac.uk.