Postdoc position in Mainz, Germany

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Website imbmainz The Institute of Molecular Biology (IMB)

Closing date: 31st January

Postdoc position in Mainz, Germany

MOLECULAR MECHANISMS OF RNA-BINDING PROTEIN DYSFUNCTION IN NEURODEGENERATIVE DISEASES

The Dormann lab investigates the molecular mechanisms of neurodegenerative diseases, most notably ALS (amyotrophic lateral sclerosis), FTD (frontotemporal dementia) and Alzheimer’s disease. They seek to unravel how certain RNA-binding proteins (RBPs), in particular TDP-43 and FUS, become mislocalized and aggregated in these disorders, and how dysregulation of these RBPs causes a decline in cell function and neurodegeneration. Their previous research demonstrated that RBP mislocalisation and aggregation in ALS and FTD are intimately linked to molecular defects in 1) nuclear import, 2) control of liquid-liquid phase separation (LLPS), and 3) post-translational modifications (PTMs). They therefore study how nuclear transport, phase separation and PTMs of these disease-linked RBPs are normally regulated, how they are misregulated in disease and how these pathological changes can possibly be reversed.

In their research, they employ biochemistry, cell/molecular biology, imaging and biophysical techniques and use a combination of cellular models, reductionist in vitro reconstitution approaches and analysis of human post-mortem brains.

For more information, visit https://www.imb.de/research/our-research-groups/dormann/research

They seek candidates with:

  • a recent (or upcoming) PhD in biochemistry, biophysics, biology or related discipline
  • extensive experience with proteomics or biophysical techniques or neuropathology is a plus
  • team spirit and enthusiasm to engage in collaborations and other lab projects
  • excellent communication skills in English
  • motivation to apply for a postdoctoral fellowship with support by the PI

Possible projects include studying disease-associated PTMs of TDP-43 and FUS and their functional impact, e.g. on the physiological functions and RNA/protein interactions of TDP-43 and FUS, their cellular localization as well as their phase separation and aggregation behavior. They also seek to analyze changes in protein solubility and PTMs in human post-mortem brains of FTD/ALS patients using proteomics approaches, and are interested in molecularly dissecting the protein/RNA interactions of TDP-43, FUS and Tau using biophysical techniques.

They offer:

  • a highly collaborative research environment and cutting edge research facilities
  • opportunity to participate in the IMB Postdoc Programme (IPPro): IMB Mainz
  • an international, diverse and fun team

Application deadline: January 31, 2022

Please send your application containing a motivation letter, CV and reference letters or contact information of two referees to Dorothee Dormann (ddormann@uni-mainz.de).

To apply for this job email your details to ddormann@uni-mainz.de.

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