Research Assistant – Protein Biochemist & Molecular Pharmacologist – 2 Posts

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Website UniofOxford University of Oxford

Closing date: 1st June

Research Assistant – Protein Biochemist & Molecular Pharmacologist – 2 Posts

University of Oxford – Centre for Medicines Discovery

The University of Oxford are seeking to appoint a Research Assistant – Protein Biochemist & Molecular Pharmacologist to join the Alzheimer’s Research UK funded Oxford Drug Discovery Institute (ARUK-ODDI) within the Centre for Medicines Discovery, University of Oxford.

You will become an integral part of project teams working on drug discovery projects playing a key part in driving the translational goals of their project teams. You will employ cutting edge biochemical and biophysical techniques to explore protein structure-function, identify novel ligands for the targets of interest, and to understand the molecular pharmacology of the target proteins. You will be responsible for the management of your own research on a number of dementia projects and administrative activities, within guidelines provided by senior colleagues. You will use and manage specialist scientific equipment in a laboratory environment, such as the liquid handling equipment (Echo, Tempest) plate readers (Pherastar, FLIPR) and biophysical equipment (Biacore, Octet, Rapid Fire). You will be responsible for the development of the, biochemical and biophysical assays and optimise them for utilisation in high-throughput screening campaigns and compound evaluation cascades. You will determine the most appropriate methodologies to test compounds and identify suitable alternatives if technical problems arise. You will have responsibility for general laboratory management and administration.

It is essential that you hold a degree in Biochemistry, Pharmacology or other Biology-related subjects, together with relevant laboratory experience. You will also have experience in protein production using bacteria, insect cells and mammalian expression systems, along with experience of establishing assay protocols, in particular enzyme activity assays, considering throughput, specificity and robustness. The ability to manage own research with an eye for detail and take responsibility for administrative activities such as management of lab reagent stock, lab book writing is required. It is essential to have good team-working skills and able to collaborate effectively within a dynamic team and matrix environment.

Excellent communication skills, including the ability to write text that can be published, present data at conferences, and represent the research group at meetings is also required.

Applications for this vacancy are to be made online and you will be required to upload a supporting statement and CV as part of your online application. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience.

This position is offered full time on a fixed term contract until 31 August 2024 and is funded by the Alzheimer’s Research UK.

Only applications received before 12 midday on 01 June 2022 will be considered. Please quote 157860 on all correspondence.

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