Research Associate: Cellular Neuroscience and iPSCs

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Website imperialcollege Imperial College London

Closing date: 16th August


The Ye Lab at Imperial College London is seeking a postdoc to investigate the build up and clearance of pathological protein aggregates associated with Alzheimer’s

The Ye lab invites applications from talented, highly motivated, and ambitious postdoctoral scientists for a Postdoctoral Research Associate (PDRA) position leading one or more projects investigating the relationship between build up and clearance of pathological protein aggregates associated with Alzheimer’s disease and activity of the ubiquitin-proteasome system. The ideal candidate will lead one or more projects exploring the role of proteasomes in the clearance of toxic aggregates derived from pathological samples. The project will unveil factors that assist proteasomes in removing protein aggregates in healthy cells and the malfunction of proteasomes in pathological cells. You will use a multidisciplinary approach (maintenance and manipulation of IPSC-neurons and established cell lines, super-resolution fluorescence imaging and various biochemical techniques) to unveil the proteostasis mechanisms and the effect of therapeutic intervention strategies on pathological aggregates.

This role is part of the Department of Brain Sciences at Imperial College London, located in the Sir Michael Uren Hub, White City Campus. Postdocs in the Ye lab at Imperial enjoy excellent career development opportunities with:

  • Access to a range of cutting-edge technologies for 2D and 3D super-resolution imaging capabilities
  • Dedicated iPSC culture facilities in the new state-of-the-art Sir Michael Uren Hub.
  • A collegial, team-oriented working environment. Follow us on Instagram!
  • National links with colleagues in the UK DRI at Imperial, weekly lab meetings jointly with colleagues from Harvard and MGH.
  • Support from the Postdoc and Fellows Development Centre (PFDC) and Imperial and UK DRI ECR Communities
  • The opportunity to mentor, supervise and teach under- and postgraduate students.

Duties and responsibilities

  • Build on your existing skills and experience to address major components of this project independently.
  • Present research findings as written reports, at conferences, within the College and as published manuscripts.
  • Take initiative in the planning of research, with clear and timely communications to the Group Leader and relevant researchers.
  • Contribute to the smooth running of the lab and facilities, acting collegiately with other scientists, clinicians, technicians and students.
  • Provide guidance to staff and assist in the supervision of undergraduate and postgraduate research students, as required.
  • Maintain highly organised and accurate records of experimental work.
  • Undertake appropriate scientific and professional training.

Essential requirements

You are a motivated and organised researcher, excited by the science we do.

With (or near completion of) a PhD in Cellular/Molecular Neuroscience with experience with IPSC cultures or in Neuropathology of Dementia (or related discipline). You will be strongly objective-driven, able to lead the project independently and put new knowledge into practice effectively.

Experimental expertise working with IPSC-differentiated neuronal culture, basic biochemistry and molecular biology is essential. Experience with advanced microscopy is a bonus.

Practical experience of quantitative image analysis, mass spectrometry or coding research projects is highly desirable in the lab.

Further Information

This position is offered full time, up to two years.

Appointments are typically made to the first spine point of the scale. Applicants who have not yet had their PhD degree awarded will be appointed to the Research Assistant scale.

For issues Interested candidates should contact Dr. Yu Ye – for a discussion about the project and role. Please attach your CV for to facilitate the discussion.

To apply, visit and search by the job reference MED04368.

To apply for this job please visit

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