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DTSTART:20260329T010000
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DTSTART;TZID=Europe/London:20261001T170000
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UID:10002392-1790874000-1790877600@www.dementiaresearcher.nihr.ac.uk
SUMMARY:Inflammation in Alzheimer's and Cancer: Swanton and Tanzi
DESCRIPTION:Two of the biggest names in cancer and Alzheimer’s genetics\, Professor Charles Swanson and Professor Rudolph Tanzi\, come together for an open discussion on the role of inflammation in both diseases. Hosted online by Consilium Scientific on Thursday 1 October 2026 at 5pm (UK time). \nAlzheimer’s disease and cancer both place a heavy load on patients\, carers and health systems in an ageing population. Up to 82 million people worldwide are predicted to be living with Alzheimer’s by 2030\, and around 26 million people are diagnosed with cancer each year. Understanding the molecular changes that start these diseases and drive them forward is key to preventing them\, spotting them early and\, where possible\, treating them. \nEvidence is building that inflammation plays a central part in both. Having each built careers on the genetics of their disease\, Swanson and Tanzi have more recently turned their attention to the role of inflammation. In this conversation they will compare and contrast how it works in cancer and Alzheimer’s\, look at what might set it off\, including environmental pollution\, and share their thinking on prevention\, early detection and possible routes to new treatments. \nThe speakers\nProfessor Charles Swanson is a clinician-scientist\, Group Leader at the Francis Crick Institute and Professor of Cancer Medicine at UCL. He is known internationally for his work on cancer evolution and tumour heterogeneity\, particularly in lung cancer\, and leads the TRACERx study tracking how cancers evolve in patients. He and colleagues published a landmark paper showing how air pollutants promote lung cancer through inflammation. \nProfessor Rudolph Tanzi is Director of the Genetics and Aging Research Unit and the McCance Center for Brain Health at Massachusetts General Hospital\, and the Joseph P. and Rose F. Kennedy Professor of Neurology at Harvard Medical School. He discovered many Alzheimer’s genes\, including the first three\, is a member of the National Academy of Medicine\, and has co-authored more than 750 papers. He has also played keyboards on albums by Aerosmith\, Joe Perry and Johnny Depp. \nBackground reading\n\nHill\, W.\, Lim\, E.L.\, Weeden\, C.E. et al. Lung adenocarcinoma promotion by air pollutants. Nature 616\, 159–167 (2023).\nButovsky\, O.\, Rosenzweig\, N.\, Kleemann\, K.L. et al. Immune dysfunction in Alzheimer disease. Nat. Rev. Neurosci. (2025).\n\nJoining details are sent to the Consilium Scientific mailing list. Sign up using the link below. \nRegister \nAdd to calendar: \nhttps://addcal.co/e/yhkmwi5d3wuf \n\nConsilium Scientific is a non-profit research organisation working to improve how clinical evidence is generated and to drive health policy change in the UK and internationally.
URL:https://www.dementiaresearcher.nihr.ac.uk/event/inflammation-alzheimers-cancer-swanton-tanzi/
LOCATION:Online
CATEGORIES:Online,Webinar
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DTSTART;TZID=Europe/London:20260924T143000
DTEND;TZID=Europe/London:20260925T200000
DTSTAMP:20260922T053655
CREATED:20260917T194123Z
LAST-MODIFIED:20260917T194123Z
UID:10002395-1790260200-1790366400@www.dementiaresearcher.nihr.ac.uk
SUMMARY:The Intelligent Genome: Powered by AI
DESCRIPTION:A two-day online symposium from the American Society of Human Genetics on how artificial intelligence and machine learning are changing the way genetic and genomic discoveries get made. Thursday 24 and Friday 25 September 2026\, 14:30–20:00 UK time (9:30am–3:00pm ET). \nSixteen speakers from universities\, health systems and industry set out what AI is actually doing in human genetics right now: predicting gene expression\, interpreting non-coding variants\, classifying variants against ClinGen specifications\, and triaging RNA-seq outliers towards a diagnosis. Talks run to thirty minutes\, with a panel discussion closing each half-day\, so there is room to put questions to the speakers. \nA good deal of it will land for people working on neurodegeneration. AlphaGenome applied to rare non-coding variant discovery\, generative models forecasting individual risk across many diseases\, and AI-derived imaging phenotypes as a route to genetic discovery all sit close to problems the dementia field is working on\, from consortium-scale genomics to variant interpretation. If you have been following agentic AI and where it might take research\, or our earlier conversation on using AI and data to fight dementia\, this is a chance to see the tooling in the hands of the people building it. \nEvent details\n\nDates: Thursday 24 and Friday 25 September 2026\nTimes: 14:30–20:00 BST each day (9:30am–3:00pm ET)\nFormat: Live online\nContinuing education: attendees are eligible to claim 6 CE\nOrganiser: American Society of Human Genetics\n\nProgramme\nTimes below are US Eastern (ET)\, as published by ASHG. Each day runs 9:30am to 3:00pm ET\, with a break from 12:00 to 1:00pm. \nDay one – Thursday 24 September 2026\n\n9:30am From Data to Insight: The Strategic Potential of AI in Human Genetics and Genomics – Ankit Malhotra\, AWS Healthcare and Life Sciences\n10:00am Evaluation of a novel AI agent for statistical genetics and target discovery – Vincent Plagnol\, Genomics Ltd\n10:30am Beyond Sequence-Based Models: Deep Hurdle Network Improves Gene Expression Prediction – Devashish Tripathi\, BRIC-National Institute of Biomedical Genomics\n11:00am Genetic discovery via AI-derived imaging phenotypes – Degui Zhi\, Yale University\n11:30am Panel discussion with all speakers\n1:00pm Unsupervised graph learning on a large-scale paediatric EHR-linked biobank – Rasika Venkatesh\, University of Pennsylvania\n1:30pm AI-enabled DNAm classification of variants in neurodevelopmental disorders – Sanaa Choufani\, The Hospital for Sick Children\n2:00pm From Hundreds of Outliers to One Diagnosis: agentic AI for scalable RNA-seq triage – Shamika Ketkar\, Baylor College of Medicine\n2:30pm Panel discussion with all speakers\n\nDay two – Friday 25 September 2026\n\n9:30am Application of AlphaGenome to rare non-coding variant discovery and interpretation – Gareth Hawkes\, University of Exeter\n10:00am VCEPilot: agentic AI execution of ClinGen VCEP specifications for expert-aligned variant classification – Xun Song\, New Jersey Institute of Technology\n10:30am MARRVEL-MCP: an agentic interface for Mendelian disease discovery – Hyun-Hwan Jeong\, Baylor College of Medicine\n11:00am Supervised generative AI for holistic germline variant summarisation – Jose Reverol\, Saphetor SA\n11:30am Panel discussion with all speakers\n1:00pm AI-enhanced quality improvement to optimise germline genetic testing in advanced prostate cancer – Kenneth Nepple\, University of Iowa Health Care\n1:30pm A generative transformer trained with genetics for forecasting an individual’s risk across many diseases – Bertram Koelsch\, 23andMe Research Institute\n2:00pm Genelio: talking to your DNA through retrieval-grounded\, ACMG-aware plain-language interpretation – Vani Priyadarsini Ikkurti\, BioAro Inc\n2:30pm Panel discussion with all speakers\n\nRegistration and fees\nRegistration is through the ASHG learning portal and rates depend on membership type and career stage. Graduate students\, undergraduates\, postdoctoral fellows\, residents\, clinical fellows and trainee members pay $55. Early career members pay $75\, regular\, emeritus and life members $95\, and non-members $120. \nRegister for The Intelligent Genome: Powered by AI \n\nThe American Society of Human Genetics is the professional membership organisation for human genetics and genomics specialists worldwide\, with members in more than 80 countries. \n 
URL:https://www.dementiaresearcher.nihr.ac.uk/event/the-intelligent-genome-powered-by-ai/
LOCATION:Online
CATEGORIES:Online,Symposium
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