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How abnormal tau impacts mitochondrial function in neurons
18/12/2025 @ 3:00 pm - 3:45 pm
Swiss Network for Dementia Research Webinar by Dr. Amandine Grimm, University of Basel.
Tauopathies such as Alzheimer’s disease are characterized by progressive neuronal dysfunction, in part driven by impaired mitochondrial bioenergetics and dynamics.
In this webinar, Dr. Grimm will start by presenting how abnormal tau impacts mitochondrial function in neurons. Then, she will present recent findings from two complementary studies conducted by her group. The first explores how abnormal tau protein influences intercellular mitochondrial transfer between astrocytes and neurons. The second study investigates the therapeutic potential of mitochondrial transplantation, showing that the exogenous delivery of healthy astrocytic mitochondria enhances bioenergetics and promotes neurite outgrowth in tauopathy neurons.
Together, these findings shed light on the mechanistic link between tau and mitochondrial communication, and open novel avenues for cell-based mitochondrial therapies in neurodegenerative disease.