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Research Showcase – Genetic Determinants of Cognitive Heterogeneity in Parkinson’s Disease

September 2 @ 8:00 pm - 8:45 pm

Strengthening Family Connections Through Reminiscence

Why do some people with Parkinson’s disease develop dementia while others do not. And how do genetic differences influence cognitive outcomes across the disease.

This livestream is part of the Dementia Researcher weekly Showcase series. Each week we host a 45 minute online session bringing researchers together to share their work, methods, and ideas.

In this session, Dr Esra Demir Unal will present her research exploring the genetic factors that contribute to cognitive heterogeneity in Parkinson’s disease. Her work investigates how rare monogenic variants, polygenic risk, and genetic loci associated with Alzheimer’s disease influence susceptibility to dementia and cognitive decline.

By combining insights from monogenic Parkinson’s disease with broader genetic risk profiles, the research aims to improve understanding of why cognitive outcomes vary between individuals and identify pathways that may support earlier prediction and more personalised approaches to care.

Esra is an Assistant Professor at Ankara Yıldırım Beyazıt University, specialising in neurogenetics and neurodegenerative disease. Her research focuses on the genetic architecture of dementia and Parkinson’s disease, with an emphasis on understanding the biological mechanisms underlying cognitive impairment.


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