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Website BristolUni University of Bristol
Closing date: 13th December
A fully funded 3-year PhD at the University of Bristol with Prof Pete Cullen, dissecting the endosomal-lysosomal network in gene-edited human neurons to understand Alzheimer’s and Parkinson’s disease. Open to UK students only. See more funded PhDs.
About the Project
Dysfunction in the endosomal-lysosomal network is a key cellular pathology found across human developmental and age-related neurological diseases including Alzheimer’s and Parkinson’s disease. Our laboratory focuses on developing and applying cutting-edge techniques to achieve a thorough mechanistic dissection of this network, translating acquired knowledge to understand neurological disease.
This fully funded 3-year PhD studentship will study endosomal-lysosomal network function in the context of human development and age-related neurological disease.
Training and Techniques: You will receive comprehensive training in core cell biology research techniques including biochemistry (especially quantitative proteomics), molecular approaches (including AlphaFold and structural methods), and cell biology using gene-edited human i3-neurons, fixed and live cell imaging.
The project will be supervised by Prof. Peter Cullen, with collaborative input from other PIs in Bristol and a network of worldwide collaborators.
We are looking for an enthusiastic and innovative student with a degree in:
- Biochemistry, Molecular Cell Biology, and/or Biomedical Sciences
Lab Culture: The successful candidate will share the core values of the Cullen lab in collaborative, multidisciplinary and open team science, conducted in a transparent, supportive and relaxed environment.
Location: Bristol is a centre for molecular cell biology research, and you will benefit from exposure to a wide range of cutting-edge research. The city of Bristol is vibrant, cosmopolitan and culturally diverse, with excellent flight connections to European cities.
Funding Notes
This studentship is funded by Professor Peter Cullen’s Royal Society Research Professorship for 3-years and consists of home UK tuition fees, as well as a stipend in line with Royal Society “outside London” rates.
Deadline for applications: Sunday 13th December 2026 at 11.59pm GMT.
References
Antón-Plágaro et al., (2025) Nature Communications 16:6990. doi: 10.1038/s41467-025-61802-1.
Kato et al., (2025) Science Translational Medicine 17:eadt2426. doi: 10.1126/scitranslmed.adt2426.
To apply for this job please visit www.findaphd.com.
