Neurofilament in Blood Foretells Early Onset Alzheimer’s
A paper published online on the 21st January in Nature Medicine finds that in familial Alzheimer’s disease, blood levels of neurofilament light (NfL) rise 16 years before the predicted age…
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CryoEM γ-Secretase Structures Nail APP, Notch Binding
In the January 11 Science, Yigong Shi, Tsinghua University, Beijing, and colleagues present a high-resolution cryo-electron microscopy structure of γ-secretase enfolding a fragment of APP. Find out more on their work from this post on the Alz Forum.
Confirmed: Human Pituitary Extract Linked to Amyloidosis Contains Aβ Seeds
Researchers from University College London have strengthened the case that certain medical procedures can transfer amyloid pathology between people.
Fits and Starts: Trial Results from the CTAD Conference
Latest on investigational treatments in the pipeline. Two-part series on recent results published at the CTAD Conference from Pat McCaffrey for the Alz Forum.
Bump in the Road or Disaster? BACE Inhibitors Worsen Cognition
Merck shook the field with news that people on verubecestat scored worse than those on placebo – find out more in this post from AlzForum
Across Time and Space: Machine Learning Reveals Paths to Dementia
Developing computational algorithms & machine-learning techniques, to transform cross-sectional imaging data to a longitudinal picture and reconstruct the sequence of disease progression.
Mixed Messages: mRNA Splicing Errors May Promote Alzheimer’s
Many genetic variants predispose to Alzheimer’s disease, but exactly how remains a mystery.
Are Tauopathies Caused by Neuronal and Glial Senescence?
In AD, tau tangles correlate closely with neurodegeneration, but how they work their mischief remains unclear… or does it?
Does Cognition Change With the Seasons?
For everything there is a season—perhaps even cognition?
AlzForum Virtual Exhibit Hall
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Does Daytime Drowsiness Foreshadow Aβ Accumulation?
https://www.alzforum.org/news/research-news/does-daytime-drowsiness-foreshadow-av-accumulation