In Alzheimer’s, More TREM2 Is Good for You
Certain mutations in TREM2 strongly increase risk for late-onset Alzheimer’s. Could tweaking the function of this microglial receptor help people with the disease?
Certain mutations in TREM2 strongly increase risk for late-onset Alzheimer’s. Could tweaking the function of this microglial receptor help people with the disease?
As microglia become more central to Alzheimer’s research, researchers are seeking better model systems to study their in vivo behavior – can chimeric mice provide a solution?
Physical activity not only benefits the heart and the body, it may also shield the brain from the damaging effects of Aβ says study published in JAMA Neurology (July 16)
In today’s JAMA Neurology, researchers led by Oskar Hansson, Lund University, Sweden, report how a fully automated immunoassay for plasma Aβ performed when they put it through its paces.
Around 140 scientists gathered in Rungstedgaard, north of Copenhagen, Denmark, May 5–9 for the biannual Brain Conference organised by the Federation of European Neuroscience Societies and the Lundbeck Foundation. This article from the Alz Forum shares news from the event.
Groups of neurons fire in sync with each other across the brain when it performs a task; however, with age, they fall out of step. Can an electrical current have a restorative effect?
On their own, most genetic variations linked to Alzheimer’s disease affect a person’s risk by a minuscule amount. Together, however, they pack a wallop, This article from Alz Forum explains.
3 years ago Michal Schwartz at the Weizmann Institute of Science, deployed an immune-boosting approach pioneered for cancer in a mouse model of Alzheimer’s disease. How has this progressed?
Brush, Floss, Take a Protease Inhibitor? Do periodontal bacteria cause some cases of Alzheimer’s disease? Scientists at one start-up think so.
A paper published online on the 21st January in Nature Medicine finds that in familial Alzheimer’s disease, blood levels of neurofilament light (NfL) rise 16 years before the predicted age…
In the January 11 Science, Yigong Shi, Tsinghua University, Beijing, and colleagues present a high-resolution cryo-electron microscopy structure of γ-secretase enfolding a fragment of APP. Find out more on their work from this post on the Alz Forum.
Researchers from University College London have strengthened the case that certain medical procedures can transfer amyloid pathology between people.
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