Science

In Alzheimer’s, More TREM2 Is Good for You

Science Research News from the Alz Forum

Certain mutations in TREM2 strongly increase risk for late-onset Alzheimer’s. Could tweaking the function of this microglial receptor help people with the disease? A new study suggests as much. In the August 28 Science Translational Medicine, researchers led by Christian Haass at the German Center for Neurodegenerative Diseases in Munich report that people with Alzheimer’s pathology who had more of a soluble TREM2 fragment in their cerebrospinal fluid declined more slowly on memory tests than did those with less sTREM2. Haass had reported preliminary data at the 2019 AD/PD conference in Lisbon, Portugal (Apr 2019 conference news). “Activating TREM2-dependent microglial functions could be a protective therapeutic approach,” Haass told Alzforum.

To read the rest of this article from the Alz Forum, visit: https://www.alzforum.org/news/research-news/alzheimers-more-trem2-good-you

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