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Catchup – Research Showcase – APOE Genotype & Dementia
March 11 @ 12:00 pm - 12:45 pm
Why do some people with genetic risk go on to experience cognitive decline while others remain resilient. How does genetic vulnerability shape pathways to later life cognitive impairment and dementia.
This livestream is part of the Dementia Researcher weekly Showcase series. Each week we host a 45 minute online session bringing researchers together to share their work, methods, and ideas.
In this session, Dr Donald Lyall, Senior Lecturer in Population Brain Health at the University of Glasgow, will present research on the role of APOE genotype in later life cognitive impairment and dementia. Donald’s work uses population health and epidemiological approaches to understand how genetic risk interacts with lifestyle and environmental factors to influence brain health and cognitive outcomes. He has extensive experience analysing large cohort datasets to uncover mediators and modifiers of cognitive decline, with a particular focus on how APOE affects vulnerability in ageing populations.
Donald will explore whether possession of specific APOE variants increases susceptibility to cognitive impairment, and what intermediate phenotypes may mediate these associations, shedding light on mechanisms that link genetic risk with cognitive health outcomes.
Attendees can expect a clear and research focused talk followed by time for questions and discussion.
