You’ve probably already heard that you should tailor your CV to each application; those who Nature spoke to agree with that suggestion. Grewlich-Gercke calls this “buzzword bingo”. Go line-by-line through the job ad and make sure there is as much of a match as possible, down to the language they use to describe certain activities. Pick out the terms they use to describe their ideal candidate and work them into your CV and cover letter: that might sate an application-scanning algorithm or AI tool, and get your CV in front of a real person.

It can be difficult to stand out from the crowd, especially if you’re coming directly from academic research, in which people tend to have similar sets of transferable skills. “That’s where doing some extracurricular activities helps a lot,” says D’Aquila. You don’t need to spend months re-training, but taking an online course or attending a seminar shows that you’re interested in going into industry and are taking active steps to make the transition. These can also be great networking opportunities. Sitara Chauhan agrees that networking will help you get noticed by potential employers. “The person you really want to get your CV to is a hiring manager,” says Chauhan, a technical sales specialist for Thermo Fisher Scientific, based in College Park, Maryland. “Even if you don’t know them well, if there’s someone who can vouch for you and get your CV directly in their e-mail, that’s how you’re going to get those interviews.”

As well as networking to develop new contacts, Chauhan says it’s important to approach existing ones. “If there are people you’ve worked with in your lab who have gone on to work in industry, reach out to them.”

It’s possible that your current employer has connections to industry that you could take advantage of, Chauhan suggests. “If your lab research involves using some instrumentation or reagents, that is a product sold by a company. You might have a sales rep for that, or an engineer who comes to the lab. Those are great people to talk to.” Let them know that you are looking for a position. “They might be connected to companies that are looking to hire,” says Chauhan, “maybe even their own company.”

Career-focused social platforms can be a good place to find old connections and start making new ones. “Messages on LinkedIn actually have a pretty good success rate,” says D’Aquila, especially if the message shows curiosity and enthusiasm, and highlights a connection between you, such as a common interest. Once you have identified someone with a role you are interested in, a connection at your target company or a former colleague who has made the switch to industry, ask for a few minutes of their time to talk about their job. These informational interviews can help you to gather information on a company and confirm that you’re applying to a position that matches your skill set, while building your professional network.

“Everybody’s a little bit afraid of doing it that way,” says Grewlich-Gercke. “But there’s a big resonance. People are often eager to share what they are doing and how they did it.”

The good news is that there are resources out there for scientists like you who want to make this transition. Your research institution might offer career-development seminars, like the Planck Academy’s industry track, at which Grewlich-Gercke helps support researchers who want to shift from academia to industry or the public sector.

Everyone Nature spoke to agreed that making this transition is a challenge — one that involves a daunting amount of time, effort and emotional turmoil. It’s easy to doubt yourself or feel disheartened after repeated rejection, but don’t give up hope. Rely on your network of friends and colleagues, and don’t be afraid to reach out to those who have gone before you. You might be surprised how willing people are to help.