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Targeting the γ-secretase protease to prevent Alzheimer’s disease would require surgical precision to shut down Aβ42 production while allowing the non-pathogenic processing of amyloid precursor protein (APP) and other important substrates to continue. Researchers just took two giant steps toward that effort with the publication of not one, but two, structures of the γ-secretase complex interacting with key substrates.
To read more on this study publication visit the Alz Forum website – https://www.alzforum.org/news/research-news/cryoem-g-secretase-structures-nail-app-notch-binding
