This talk by Dr Jacob Vogel was recorded on 26th March 2026 by the DEMON Network Biomarkers Working Group.
Dr Jacob Vogel is a researcher at Lund University in Sweden, within the Department of Clinical Sciences Malmö, and a fellow of SciLifeLab. He leads the Dementia, Multiomics and Neuroimaging Lab, where his work focuses on applying data science approaches to clinical datasets, including neuroimaging, biofluids, and multiomic data, to better understand neurodegenerative diseases and develop clinically useful tools.
In this session, hosted by Dr Laura Winchester, Jacob explores how high throughput proteomics is opening up new ways to understand neurodegenerative disease biology. He discusses how analysing proteins in cerebrospinal fluid and plasma can reveal previously hidden disease pathways, track progression, and support the development of biomarkers with real world clinical potential.
The talk highlights key findings from recent studies in Alzheimer’s disease, Parkinson’s disease, and cerebrovascular disease, including the identification of novel protein signatures linked to disease stages, subtypes, and progression. Jacob also introduces approaches using AI and data science to translate complex proteomic data into predictive models, while addressing challenges such as variability across datasets and methodological pitfalls like data leakage.
A central theme of the discussion is the balance between biological insight and clinical application. While cerebrospinal fluid proteomics provides detailed and precise information about brain processes, plasma proteomics offers a scalable route toward accessible diagnostics. Together, these approaches present opportunities for earlier detection, improved stratification of patients, and more targeted therapeutic development.
This conversation offers a clear overview of how proteomics is reshaping the study of neurodegenerative diseases, while also acknowledging the work still needed before these tools can be fully integrated into clinical practice.
Find out more about Jacob and his work:
https://portal.research.lu.se/en/persons/jacob-vogel
Find out more about the DEMON Network and how you can get involved in their work:
https://demondementia.com/
DEMON Network
Dementia Researcher
UK DRI
