Neurodegenerative Diseases

As the population ages, the incidence of neurodegenerative diseases is increasing, thus creating a major public health problem given the virtual lack of effective treatments for these complex diseases. Fortunately, new technological advances impacting basic science, genetics and translational research are enabling the discovery of novel risk genes and disease pathways, and the development and testing of potential therapeutics. Indeed, modern genomic, epigenomic and biological tools including gene editing, spatial transcriptomics, single molecule fluorescence, viral vector engineering, and organoid development have greatly contributed to discoveries revealing the importance of immune mechanisms, RNA metabolism, and lysosomal biology in neurodegenerative disease pathogenesis.

This conference will bring together leaders in basic, clinical and translational research to discuss their latest findings and novel concepts on these topics. In addition, the program will highlight new and emerging models, tools and technologies allowing a more comprehensive understanding of neurodegenerative diseases. Finally, the pairing of this conference with the Neuroimmune Interactions: Nervous System and Immune Cell Heterogeneity in Health and Disease conference will foster interdisciplinary insights and collaborations towards identifying immune pathology and therapeutic targets for multiple neurodegenerative disorders, where promising new treatments are emerging.

Organizers: Leonard Petrucelli, Stacie Weninger & Soyon Hong

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Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives