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Research Showcase – Sex Differences and Molecular Pathways in Vascular Dementia

April 1 @ 8:00 pm - 8:45 pm

Sex Differences and Molecular Pathways in Vascular Dementia

How do small vessel changes in the brain contribute to vascular dementia. And why might disease pathways differ between males and females.

This livestream is part of the Dementia Researcher weekly Showcase series. Each week we host a 45 minute online session bringing researchers together to share their work, methods, and ideas.

In this session, Dr Daniel Ruiz Gabarre will present his research on vascular dementia using a preclinical rat model of small vessel disease. His work focuses on the Atp11b gene, which encodes a phospholipid flippase involved in transporting phosphatidylserine and phosphatidylethanolamine, and how disruption of this pathway contributes to vascular pathology and cognitive impairment.

Using transcriptomics and proteomics approaches, Daniel investigates the molecular mechanisms underlying disease progression, with a particular focus on sex differences and how these may shape vulnerability and outcomes in vascular dementia.

Daniel is a researcher at the University of Edinburgh specialising in vascular contributions to cognitive impairment and dementia. His work combines experimental models with molecular profiling techniques to better understand mechanisms driving small vessel disease.

Attendees can expect a research focused session with time for questions and discussion.


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