Profile – Professor Tara Spires-Jones, The University of Edinburgh

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Professor Tara Spires-Jones


Professor Tara Spires-Jones

Job title:

Professor of Neurodegeneration & Deputy Director, Centre for Discovery Brain Sciences

Place of work / study:

UK Dementia Research Institute at the University of Edinburgh

Area of Research:

Neuroscience, Neurobiology of synapse degeneration

How is your work funded?

UK Dementia Research Institute Programme, European Research Council Consolidator Award, Alzheimer’s Research UK, Alzheimer’s Society

Tell us a little about yourself:

Tara Spires-Jones is Professor of Neurodegeneration at the University of Edinburgh where she is Deputy Director of the Centre for Brain Sciences and a UK Dementia Research Institute Fellow. Her research focuses on the mechanisms and reversibility of neurodegeneration in Alzheimer’s disease, other degenerative brain diseases, and ageing. Working with a vibrant group of researchers, she is trying to understand why synapses and neurons become dysfunctional and die in these diseases in order to develop effective therapeutic strategies. Her work has shown that soluble forms of the pathological proteins amyloid beta and tau contribute to synapse degeneration, and that lowering levels of these proteins can prevent and reverse phenotypes in model systems. Further, she has pioneered high-resolution imaging techniques in human post-mortem brain and found evidence that these proteins accumulate in synapses in human disease. Tara Spires-Jones has published over 100 peer reviewed papers which have been cited over 10,000 times.

Prior to moving to Scotland in 2013, Tara Spires-Jones ran a group studying Alzheimer’s disease pathogenesis with an emphasis on synaptic pathology at Massachusetts General Hospital (MGH) and Harvard Medical School, where she was Instructor from 2006-2011 and Assistant Professor from 2011-2013. She completed graduate training (MSc and DPhil) at the University of Oxford from 1999-2003, and undergraduate training at the University of Texas at Austin from 1994-1999.

In addition to her research, Prof Spires-Jones is passionate about communicating scientific findings to the public and policy makers; increasing the rigour and reproducibility in translational neuroscience; promoting inclusivity and diversity in science; and supporting career development of neuroscientists. She is a founding member of the FENS-Kavli Network of Excellence, which works to promote the future of European Neuroscience. She served as a member of the Scottish Science Advisory Council from 2016-2019 advising the Scottish Government on science policy, and in 2018 was elected as a term Member of the European Dana Alliance of the Brain promoting public engagement with neuroscience

Tell us a fun fact about yourself:

I’m a massive SciFi fan and spend most of my spare time reading novels and playing with my 2 kids, dog and cat. My first job was shovelling horse manure in Texas during the summers (a very warm job).

Why did you choose to work in dementia?

I’m fascinated by how synapses function and how they go wrong in disease. I got into Alzheimer’s research because of the link between synapse loss and cognitive decline, and because I was impressed by the microscopes in my postdoc mentor’s lab (he is an Alzheimer expert), which provided an amazing way to study this.

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