Drilling Down into the CMS Aduhelm Decision
Medicare limits Aduhelm coverage to clinical trials, but OKs registry-based studies for traditionally approved anti-Aβ antibodies
All posts by Alz Forum
Benzodiazepines Coax Microglia to Prune Synapses, Impair Cognition
Long-term use of benzodiazepines, commonly prescribed for anxiety, may impair cognition and increase the risk of developing dementia – news from Alz Forum.
Identical Twins Share Tau Trajectory, but Lifestyle Helps
Identical twins share the same womb, the same genome—and, it turns out, the same pattern of neurofibrillary tangles. Shared from the AlzForum
Not All Bad? APOE4 Sharpens Memory in Older People
APOE4, the strongest genetic risk factor for sporadic Alzheimer’s disease, & has been tied to slightly better memory in the young.
From a 1m Samples, GWAS finds 7 New Alzheimer’s Spots
It took more than 1m samples, but researchers have managed to extract 7 fresh Alzheimer’s loci. Published September 7 in Nature Genetics.
Can Exercise Protect People Whose Plasma Tau Is Up?
Staying active has many health benefits, including, perhaps, to help preserve memory. Alas, is this true in some more than others?
On Donanemab, Plaques Plummet. Off Donanemab, They Stay Away
If clearance of amyloid would be “reasonably likely” to bestow a cognitive benefit – setting the bar rather blow there other antibodies
Clinicians respond to Aducanumab news
The FDA’s approval of aducanumab has given physicians a new treatment option, but little guidance on how to put it into practice.
Stunning Diagnostic Accuracy from a Plasma Protein Panel?
Blood tests for Alzheimer’s rely on Aβ & Phosphorylated tau, they are 90% accurate, a new study suggests that a broad protein panel can do better.
Does ApoE in Neurons Drive Vulnerability in Alzheimer’s?
Study published May 6 in Nature Neuroscience makes the case that neuronal ApoE not only signals distress, but also may have a hand in killing the neurons.
Microglia Build Plaques to Protect the Brain
Could it be that microglia build plaques rather than bust them? Research has produced new evidence for this idea. Update from the Alz Forum
Are the Long Aβ Peptides the Real Bad Guys?
New discover around mutations in the transmembrane domain of Aβ-protein precursor cause early onset familial Alzheimer’s disease.