Aβ in Lewy Body Disease: 2 Diseases at Once?
Alz ForumMany people with Lewy body diseases (LBDs) ultimately develop dementia, and many have Aβ plaques & tau. Do they have two diseases at the same time?
Science
Confused About the DIAN-TU Trial Data? Experts Discuss
At the virtual AAT-AD/PD Focus meeting, clinicians and funders involved in the DIAN-TU Trial discuss results from the first DIAN-TU treatment trial
Blog – Stress and Alzheimer’s, what do we know so far?
Sarah GregoryCan stress increase dementia risk? Sarah Gregory explores cortisol, Alzheimer’s, and what research reveals about this complex connection.
Tau2020 Global Conference
Tau2020 united 650 researchers, marking a key moment in tauopathy research with breakthroughs from progression staging to new ligands and tau spread insights.
Can BACE2 Protect Against Amyloidosis?
Dementia ResearcherIt may seem counter intuitive, but could BACE2 protect against amyloidosis, rather than contribute to it? Find out in the post shared from the Alz Forum website
Alzforum’s Dataset of APP Mutations Gets a Makeover
The notorious amyloid precursor protein, central to Alzheimer’s disease pathogenesis, sports a new look on Alzforum’s Mutations database – open access
Human and Mouse Microglia React Differently to Amyloid
Human and mouse brains respond differently to amyloid. A new study reveals why transgenic mice may fall short in modelling Alzheimer’s disease.
Does a Breached Blood-Brain Barrier Cause Seizures in AD?
Ageing weakens the blood-brain barrier, triggering TGFβ signalling, hyperexcitation, and memory loss; in mice, a TGFβ blocker prevents these effects.
The Human Brain Hosts a Menagerie of Microglia
Human brain biopsies reveal 14 types of microglia, from calm to inflammatory. Their states shift with age, disease, and brain region, upsetting cellular balance
Microscopic advances opening opportunities in cell biology
Nature Careers BlogCryo-EM lets scientists see large biomolecules at near-atomic resolution. Kühlbrandt called it the ‘Resolution Revolution’ for its impact on structural biology.
Beyond CRISPR: A New Editing Tool
CRISPR wasn’t the answer for Xingxu Huang. Discover how base editors offer a more precise way to correct genetic mutations, one DNA letter at a time.
Can Kelp Help Treat AD? Chinese Regulators Think So
GV-971, a seaweed-derived drug, gains conditional approval in China to treat mild to moderate Alzheimer’s, with global trials set to start in 2020.