Dr Byron Creese, Senior Research Fellow at the University of Exeter introduces the concept of Mild Behavioral Impairment (MBI), and presents his recent research into prevalence and cognitive correlates in healthy older adults and introduce new findings on genetic associations.
Early identification of people in the evolving stages of Alzheimer’s disease (AD) is a key priority for clinical trials and ultimately for clinical practice. PET and CSF biomarkers are scientifically valid approaches but are not feasible at a population level, therefore straightforward cost-effective approaches are urgently needed. Later-life emergent neuropsychiatric symptoms, known as MBI, are associated with progressive cognitive decline, even in individuals without significant cognitive impairment. Being easily-measured and scalable, MBI may represent an invaluable opportunity to identify people at pre-clinical and even pre-cognitive stages of disease. However, the critical question of whether MBI is prodromal or risk factor remains.
This Midday Lecture Webinar was recorded on the 14th May 2020 and is brought to you by the NIHR Dementia Researcher Website, and hosted by Adam Smith, Programme Director at the Office of the NIHR National Director for Dementia Research, University College London
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