Poster Talks from ADPD 2026 | Watch the Playlist

At ADPD 2026, Eimear Murphy from UCL Queen Square Institute of Neurology presents research using stable isotope labelling kinetics to study biomarker dynamics in cerebrospinal fluid.

This work explores how protein turnover and kinetic profiles of candidate biomarkers change in vivo, offering a more dynamic view of neurodegeneration. Using SILK, the study measures biomarker half lives and turnover rates, providing insight into disease progression beyond static measurements.

The findings suggest that tracking biomarker kinetics could improve understanding of neurodegenerative processes and support more sensitive approaches to monitoring disease activity and treatment response.

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At ADPD 2026, Ida Pesämaa from the University of Gothenburg presents research exploring biomarker candidates ferritin and FABP3 and their role in an iron lipid axis in microglia.

This study investigates how iron accumulation and lipid dysregulation interact within microglial cells. The findings show that iron overload is linked to increased ferritin and FABP3 expression, pointing to a combined iron lipid pathway that may influence microglial function and neuroinflammation.

This work highlights microglia as a central player in Alzheimer’s disease mechanisms and identifies ferritin and FABP3 as potential biomarkers and targets for further study.

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At ADPD 2026, Gabriella Fiorino from the Mayo Clinic presents research exploring how activation of the kinase PINK1 influences mitochondrial function and neuronal resilience in Parkinson’s disease.

Using iPSC derived cells and animal models, this study examines how increased PINK1 activity affects mitochondrial health, cellular survival, and neurodegeneration related pathways. The findings show improved mitochondrial function and enhanced resilience in neuronal systems.

This work highlights the role of mitochondrial quality control in Parkinson’s disease and supports targeting PINK1 as a potential therapeutic strategy.

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At ADPD 2026, Hannah Macpherson from the UK Dementia Research Institute, University of Cambridge and UCL, presents research exploring how the SNCA A53T variant alters gene expression in Parkinson’s disease.

Using iPSC derived neurons and long read sequencing approaches, this study examines allelic bias in SNCA expression and how this mutation shifts transcript usage. The findings show that the A53T variant changes transcriptional balance, affecting RNA processing and isoform expression.

This work provides insight into how genetic variation influences alpha synuclein biology and highlights transcriptional regulation as a key mechanism in Parkinson’s disease.

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At ADPD 2026, Priya Suman from the University of Ottawa presents research exploring how viral infection may influence alpha synuclein biology in Parkinson’s disease.

Using both in vitro and in vivo models, this study examines how virus exposure changes alpha synuclein signal, aggregation related processes, and immune responses. The findings suggest that infection linked mechanisms may shape disease relevant pathways and influence how alpha synuclein behaves in the nervous system.

This work adds to growing interest in the relationship between infection, inflammation, and neurodegeneration, highlighting a possible link between viral exposure and Parkinson’s disease biology.

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At ADPD 2026, Thais Rafael Guimaraes from the University of Pittsburgh presents research using marmoset models alongside in vitro approaches to study Alzheimer’s disease mechanisms.

This work combines ex vivo and cellular models to investigate tau biology and transcriptional changes, bridging findings from animal models to human disease.

The study highlights how alternative model systems can improve understanding of disease pathways and support translational research.

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At ADPD 2026, Paulina Mayer from the Mannheim Center for Clinical and Translational Neuroscience presents research examining brain volume loss in primary brain calcification.

Using imaging and biomarker approaches, this study explores structural changes and their relationship to disease progression.

The findings contribute to understanding how brain calcification relates to neurodegeneration and may support improved diagnosis and monitoring.

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At ADPD 2026, Claire Helena Webster from McGill University presents work on bridging academia and community to improve education and support for people living with dementia and their caregivers.

This initiative focuses on developing accessible educational resources for healthcare professionals, students, and family care partners, grounded in lived experience.

The work highlights how education, outreach, and collaboration can strengthen dementia care and better support those affected in everyday life.

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At ADPD 2026, David Steven Priemer from the Uniformed Services University of the Health Sciences presents research examining chronic traumatic encephalopathy in military populations.

Using data from the United States Department of War and Uniformed Services University Brain Tissue Repository, this work investigates the relationship between head trauma exposures and CTE pathology.

The study compares different exposure types, including contact sports, civilian traumatic brain injury, and blast exposure, providing insight into relative risk and patterns of disease in military cohorts.

https://researchbraininjury.org

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At ADPD 2026, Axelle Versavel from Ghent University presents research using multi omics profiling to uncover molecular pathways involved in RNF216 mediated neurodegeneration.

Combining transcriptomic and proteomic analyses, this study explores how disruptions linked to RNF216 affect cellular processes and contribute to disease.

The findings provide insight into mechanisms underlying rare neurodegenerative conditions and highlight potential targets for future research.

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At ADPD 2026, Selma Polte from Carl von Ossietzky University Oldenburg presents research examining intraindividual variability in cognitive performance in Parkinson’s disease.

Using repeated smartphone based Symbol Digit Modalities Test assessments, this longitudinal study captures real world cognitive fluctuations over time.

The findings highlight how variability in cognition may serve as an early marker of decline and support new approaches to monitoring Parkinson’s disease in daily life.

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At ADPD 2026, Connie MacKenzie Gray Scott from Newcastle University presents research using adult human organotypic brain slice cultures to study tau pathology and neurodegeneration over time.

This work shows how phosphorylated tau and glial changes develop progressively in culture, providing a model to examine disease mechanisms in human tissue.

The study offers a valuable platform for understanding tau driven pathology and testing potential therapeutic approaches.

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At ADPD 2026, Olivia Todd from the @ukdementiaresearchinstitute at the University of Edinburgh presents research identifying synaptic targets linked to resilience in Alzheimer’s disease.

Using a targeted transcriptomic approach in human post mortem brain tissue, this study explores differences in gene expression associated with cognitive resilience despite Alzheimer’s pathology.

The findings highlight potential synaptic mechanisms that may help protect brain function and inform future therapeutic strategies.

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At ADPD 2026, Riikka Immonen from Charles River Discovery Research Services presents research on amyloid related imaging abnormalities in a 5xFAD mouse model of Alzheimer’s disease following treatment with an anti amyloid antibody.

This longitudinal study examines how antibody treatment influences ARIA, including microbleeds and vascular changes, and how these effects evolve over time.

The work provides insight into treatment related imaging changes and helps improve understanding of safety and response in anti amyloid therapies.

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At ADPD 2026, Riikka Immonen from Charles River Discovery Research Services presents research using functional ultrasound to assess cerebral perfusion deficits in a mouse model of chronic stress induced depression.

This study explores how chronic restraint stress affects brain blood flow, vascular responses, and behaviour, providing insight into how stress related changes may impact brain function.

Using advanced imaging techniques, this work highlights how functional ultrasound can be used to study neurovascular changes linked to mood and neurological conditions.

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At ADPD 2026, Emma Monte from Pepperdine University presents research exploring ghrelin response to a MIND diet and mindset intervention in women.

This study investigates how dietary patterns combined with behavioural approaches may influence hormone regulation linked to appetite, metabolism, and broader health outcomes.

By focusing on physiological responses to lifestyle interventions, this work contributes to understanding how diet and mindset may interact with pathways relevant to brain health and disease risk.

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At ADPD 2026, Maya Willey from the National Institutes on Aging presents research exploring how hormone related medication use may influence Alzheimer’s disease risk.

Using large cohort data, this work examines how timing, duration, and type of exposure could shape risk, highlighting the complexity of hormonal influences across the lifespan.

This research adds to growing evidence around sex differences and biological risk factors in Alzheimer’s disease, helping to refine how we understand prevention and risk modelling.

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Amelia Smith from the University of Oxford presents her poster at the AD PD Conference in Copenhagen.

Her research explores how PINK1 loss of function mutations affect mitophagy in dopaminergic neurons derived from iPSCs, and how these cells respond to Parkinson’s disease associated toxins.

The poster shows how impaired mitochondrial quality control may increase vulnerability to environmental stressors, highlighting interactions between genetic risk and external exposures.

By combining cellular models with toxin exposure studies, this work provides insight into disease mechanisms and helps explain how genetic and environmental factors may work together in Parkinson’s disease.

This video is part of our Poster in a Short series from AD PD 2026, continuing from day 3, bringing you quick snapshots of dementia research straight from the conference floor.

More poster presentations are coming soon, showcasing the people and ideas shaping dementia research.

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Nwanyieze Ngozi Jiakponnah from Wake Forest University School of Medicine presents her poster at the AD PD Conference in Copenhagen.

Her research explores how multidomain social engagement relates to cognitive decline and dementia risk among geographically diverse individuals of African ancestry.

Using longitudinal cohort data, the study examines different types of social engagement, including social, cultural, and behavioural factors, and how these influence cognitive trajectories over time.

The poster highlights how protective effects of social engagement may vary across contexts, emphasising the importance of culturally relevant approaches to dementia prevention and risk reduction.

These findings support more tailored, population specific strategies to promote cognitive health and reduce dementia risk.

This video is part of our Poster in a Short series from AD PD 2026, continuing from day 3, bringing you quick snapshots of dementia research straight from the conference floor.

More poster presentations are coming soon, showcasing the people and ideas shaping dementia research.

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Sofia Caterina Gentile from the University of Toronto presents her poster at the AD PD Conference in Copenhagen.

Her research uses imaging mass cytometry to map immune cell activity in the brains of people with progressive supranuclear palsy. This approach allows detailed spatial profiling of immune responses alongside tau pathology.

The poster highlights how immune activation and inflammation are distributed across different brain regions, offering new insight into how these processes interact with disease mechanisms in tauopathies.

These findings help build a clearer picture of the role of neuroinflammation in PSP and may support the development of targeted therapeutic strategies.

This video is part of our Poster in a Short series from AD PD 2026, continuing from day 3, bringing you quick snapshots of dementia research straight from the conference floor.

More poster presentations are coming soon, showcasing the people and ideas shaping dementia research.

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Stina Saunders from Linus Health presents her poster at the AD PD Conference in Copenhagen.

Her research explores the feasibility and acceptability of the ePSOM tool, a digital outcome measure designed to capture what matters most to individuals living with neurodegenerative disease.

The poster highlights findings from global Alzheimer’s disease trials, including work in Japanese memory clinics, showing that ePSOM can capture personalised treatment priorities and translate them into structured, measurable endpoints.

This approach represents a shift towards more meaningful, patient centred outcomes in clinical trials, supporting better evaluation of therapeutic impact beyond traditional measures.

This video is part of our Poster in a Short series from AD PD 2026, continuing from day 2, bringing you quick snapshots of dementia research straight from the conference floor.

More poster presentations are coming soon, showcasing the people and ideas shaping dementia research.

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Sophie Louise Farrow from the University of Oxford presents her poster at the AD PD Conference in Copenhagen.

Her research uses 3D chromatin interaction data to prioritise target genes linked to sporadic Parkinson’s disease. By integrating chromatin conformation mapping, RNA sequencing, and publicly available datasets, the work moves beyond traditional GWAS signals to identify functional gene targets.

The poster highlights how disease associated variants connect to gene regulation in relevant cell types, including dopamine neurons and microglia, helping to clarify the biological pathways involved.

These findings provide a more precise way to interpret genetic risk and identify potential therapeutic targets in Parkinson’s disease.

This video is part of our Poster in a Short series from AD PD 2026, continuing from day 2, bringing you quick snapshots of dementia research straight from the conference floor.

More poster presentations are coming soon, showcasing the people and ideas shaping dementia research.

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Sofie Frandsen from Vesper Bio presents her poster at the AD PD Conference in Copenhagen.

This work explores how inhibiting sortilin with the oral small molecule VES001 increases progranulin levels, a key protein implicated in neurodegenerative diseases including frontotemporal dementia and Parkinson’s disease.

The poster presents Phase 1b and 2a data in GRN mutation carriers, showing increased progranulin levels in plasma and CSF, alongside a favourable safety profile. It also highlights biomarker analyses linked to neuroinflammation, lysosomal function and synaptic health.

These findings support sortilin inhibition as a promising therapeutic strategy targeting underlying disease biology, with potential to modify disease progression.

This video is part of our Poster in a Short series from AD PD 2026, continuing from day 2, bringing you quick snapshots of dementia research straight from the conference floor.

More poster presentations are coming soon, showcasing the people and ideas shaping dementia research.

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Rikke Hahn Kofoed from Aarhus University presents her poster at the AD PD Conference in Copenhagen.

Her research explores how focused ultrasound can enhance delivery of gene therapies to deep brain regions. The poster shows how intra CSF AAV delivery combined with ultrasound improves distribution across key brain areas in both rodent and primate models.

This approach could help overcome one of the major challenges in gene therapy for neurodegenerative diseases, enabling more targeted and effective delivery to affected brain regions.

The findings highlight a promising strategy for advancing treatments in synucleinopathies and other neurological conditions.

This video is part of our Poster in a Short series from AD PD 2026, continuing from day 2, bringing you quick snapshots of dementia research straight from the conference floor.

More poster presentations are coming soon, showcasing the people and ideas shaping dementia research.

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Tatiana Georgiades from Imperial College London, @ukdementiaresearchinstitute presents her poster at the AD PD Conference in Copenhagen.

Her research explores how the synaptic proteome changes during Alzheimer’s disease progression, focusing on how alterations in synaptic proteins relate to cognitive decline.

The poster highlights distinct protein expression patterns across disease stages and identifies synaptic signatures linked to pathological progression. It also proposes candidate biomarkers, including PHGDH, that may help track synaptic dysfunction and disease advancement.

These findings offer insight into the biological mechanisms underlying synapse loss and open up potential avenues for earlier detection and targeted intervention.

This video is part of our Poster in a Short series from AD PD 2026, continuing from day 2, bringing you quick snapshots of dementia research straight from the conference floor.

More poster presentations are coming soon, showcasing the people and ideas shaping dementia research.

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Alexander John Kaula from Cambridge Cognition presents his poster at the AD PD Conference in Copenhagen.

His research explores the feasibility of using smartphone based cognitive assessments to monitor people with Parkinson’s and Huntington’s disease. The study looks at how well participants engage with remote testing over time, and what factors influence adherence.

The poster highlights patterns in participation, including how scheduling and study design affect completion rates, and shows that remote digital assessments can provide reliable and scalable ways to track cognitive change in neurodegenerative conditions.

This video is part of our Poster in a Short series from AD PD 2026, continuing from day 2, bringing you quick snapshots of dementia research straight from the conference floor.

More poster presentations are coming soon, showcasing the people and ideas shaping dementia research. #adpd2026

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Millie Beament from University College London presents her poster at the AD PD Conference in Copenhagen.

Her research examines the test retest reliability of plasma p tau217, a promising blood based biomarker for Alzheimer’s disease. The poster explores how consistent measurements are over time and across platforms, and what this means for its use in clinical and research settings.

Using paired plasma samples, the study shows strong reliability alongside some within subject variability, highlighting both the potential and the considerations needed when using p tau217 in diagnosis and monitoring.

This video is part of our Poster in a Short series from AD PD 2026, continuing from day 2, bringing you quick snapshots of dementia research straight from the conference floor.

More poster presentations are coming soon, showcasing the people and ideas shaping dementia research.

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Megan Hodgson from PSPA presents her poster at the AD PD Conference in Copenhagen.

Her research explores the diagnostic journey for people living with Progressive Supranuclear Palsy and Corticobasal Degeneration, and how delays and misdiagnosis affect quality of life.

Drawing on survey data, the poster highlights how long it can take to receive an accurate diagnosis, the number of healthcare visits involved, and the impact this has on access to care, support, and wellbeing for both patients and families.

The findings underline the need for earlier recognition, clearer referral pathways, and improved support following diagnosis.

This video is part of our Poster in a Short series from AD PD 2026, continuing from day 2, bringing you quick snapshots of dementia research straight from the conference floor.

More poster presentations are coming soon, showcasing the people and ideas shaping dementia research.

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Leonardo Biscetti from the Italian National Research Center on Aging presents his poster at the AD PD Conference in Copenhagen.

His research explores how personality traits influence dementia risk, and how this relationship is shaped by modifiable risk factors. Using large longitudinal datasets including HRS, NHATS and ELSA, the study examines how traits like neuroticism and conscientiousness relate to Alzheimer’s disease and vascular dementia.

The poster shows that some of this risk is mediated through factors such as physical activity, smoking, depression, and cardiometabolic health, helping to identify pathways where intervention may reduce risk.

This video is part of our Poster in a Short series from AD PD 2026, now continuing from day 2, bringing you quick snapshots of dementia research straight from the conference floor.

More poster presentations are coming soon, showcasing the people and ideas shaping dementia research. #adpd2026

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Antigone Fogel from Imperial College London presents her poster at the AD PD Conference in Copenhagen.

Her work explores how electronic health record data can be used to predict five year risk of Alzheimer’s disease and vascular dementia. Using large scale patient datasets, she identifies patterns and risk factors that emerge years before diagnosis.

The poster shows how predictive models can track changing risk over time, highlighting key clinical features linked to both Alzheimer’s and vascular dementia, and demonstrating how these approaches could support earlier detection and intervention.

This video is part of our Poster in a Short series from AD PD 2026, now continuing into day 2, bringing you quick snapshots of dementia research straight from the conference floor.

More poster presentations are coming soon, showcasing the people and ideas shaping dementia research.

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Pavle Krizan from the Central European Institute of Technology at Masaryk University presents his poster at the AD PD Conference in Copenhagen.

His research explores how alpha synuclein changes shape and structure using NMR spectroscopy and other biophysical methods. The poster focuses on the balance between monomer, trimer and tetramer forms, and how these influence aggregation linked to Parkinson’s disease.

He shows how factors like N terminal acetylation affect fibril formation and aggregation kinetics, helping to explain how structural changes may drive disease mechanisms.

This video is part of our Poster in a Short series from AD PD 2026, bringing you quick snapshots of dementia research straight from the conference floor.

More poster presentations are coming soon, showcasing the people and ideas shaping dementia research.

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Institute of Pharmacology and Toxicology at Ludwig Maximilians University Munich presents her poster at the AD PD Conference in Copenhagen.

Her research focuses on the endolysosomal system and how ion channel dysfunction may contribute to Alzheimer’s and Parkinson’s disease. The poster brings together evidence from human iPSC derived neurons and patient fibroblasts, showing impaired neuronal activity, altered lysosomal function, and increased amyloid related changes.

She also highlights how targeting lysosomal ion channels can restore aspects of cellular function, pointing towards new therapeutic approaches.

This video is part of our Poster in a Short series from AD PD 2026, bringing you quick snapshots of dementia research straight from the conference floor.

This is the first in the series, with many more poster presentations coming soon, showcasing the people and ideas shaping dementia research.

#dementiaresearch

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