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Donatella Di Rienzo
Name:
Donatella Di Rienzo
Job Title:
DPhil Student / Research Assistant
Place of work / study:
The ARUK Oxford Drug Discovery Institute
Area of Research:
My research focuses on the LDL receptor and its regulator, IDOL, in the context of Alzheimer’s disease. I aim to explore ApoE/amyloid beta clearance pathways via the LDL receptor in hiPSC-derived macrophages as a potential therapeutic strategy.
How is your work funded:
Tell us a little about yourself:
I was born in Molise, Italy, and moved to England when I was young. My interest in science grew during school, and a Nuffield Research Placement one summer confirmed my interest for neurodegenerative research. After completing my Master’s in Translational Neurology at UCL, I joined the Oxford Drug Discovery Institute (ODDI) as a protein scientist in the neuroinflammation team. The ODDI focuses on translating cutting-edge academic science into dementia therapeutics—something I am truly passionate about. Now a third-year DPhil student at the ODDI, I am particularly interested in lipid metabolism and neuroinflammation in Alzheimer’s disease. I also serve as an early career researcher representative on the ARUK Thames Valley Network Committee, where we facilitate networking, public engagement, and professional development opportunities for ECRs to share their exciting research. Outside the lab, I enjoy singing in a choir, attempting to make my own clothing, and baking—lots and lots of baking!
Tell us a fun fact about yourself:
Not sure.
Why did you choose to work in dementia:
My interest in science, particularly neuroscience, was sparked by my grandfather’s experience with Alzheimer’s. Seeing the impact of the disease firsthand motivated me to pursue research that could contribute to a better understanding and potential treatments for dementia.
What single piece of of advice would you give to an early career researcher?
One piece of advice I’d offer to fellow ECRs is to find opportunities to share your research regularly. Whether it’s through presentations, discussions, or networking events, getting feedback from others can be invaluable in refining your work and expanding your ideas.
