Which Cell Types Execute Your Genetic Risk? For AD and PD, Scientists Know.

From the Alz Forum

Reading Time: < 1 minute

Genome-wide association studies have uncovered a thicket of risk variants for neurologic diseases, but in which cells are these disease genes doing their dirty work?

Merging GWAS with gene-expression signatures across the mouse nervous system, researchers led by Jens Hjerling-Leffler and Patrick Sullivan of the Karolinska Institute in Stockholm predict the primary cell types driving genetic risk in multiple neurological disorders. In Alzheimer’s disease, unsurprisingly perhaps, microglia were the prime suspects. For Parkinson’s, dopaminergic neurons, gut neurons and, lo and behold, oligodendrocytes expressed a preponderance of risk genes. Published April 27 in Nature Genetics, the study could help researchers home in on precise cellular targets for each disease.

Click here to read this article in full on the Alz Forum

Leave a Reply

Join the Community

We’re changing the way our website works. You previously has to be a registered member to view some areas of our website, we have now opened some of these sections to everyone. However, we want to let you know that as a registered member you’ll recieve our weekly bulleting, have access to jobs and other pages, and have the ability to comment and join groups. Registration is free and only takes 1 minute.

Register Now


I already did it / I don’t want to register – close this box

Translate »